Scientific Director - Professor L.S. Mhitaryan
Department of Clinical Biochemistry
The department was founded in 1961.
The main direction of research is experimental and clinical studies of molecular and membrane mechanisms of the initiation and progression of cardiovascular diseases.
The researches assess the role of changes of metabolic processes, and structural and functional state of cellular membranes (cardiomyocytes, endothelial cells, erythrocytes, thrombocytes, lymphocytes). A great attention is paid to the analysis of the role of intensification of free radical oxidative reactions in the modification of lipid components of lipoproteins, blood proteins during the development and progression of cardiovascular diseases. Biochemical content, structural organization and main properties (barrier and ion-transport properties, receptors and antigens) of cellular membranes, the factors of neurohumoral regulation of metabolism, density and sensitivity of beta-adrenoreceptors, the activity of angiotensin converting enzyme, transmembrane ion gradients, concentration of intracellular calcium are studied. Biochemical criteria of patient selection for pathogenetically substantiated prescription of new drugs and the estimation of their efficacy have been developed in collaboration with other clinical departments of the Institute.
The modern methods of research are used at department, such as: differential ultracentrifugation, spectrophotometry, chromatography, nephelometry, radioligand binding, immunoenzymatic and other techniques.
During the last decade 280 scientific works were published, including 115 abroad, 5 guidelines, 15 inventions were patented. 7 candidate’s and 1 doctoral degrees in medicine have been given to the scientists of the department.
The main direction of research is experimental and clinical studies of molecular and membrane mechanisms of the initiation and progression of cardiovascular diseases.
The researches assess the role of changes of metabolic processes, and structural and functional state of cellular membranes (cardiomyocytes, endothelial cells, erythrocytes, thrombocytes, lymphocytes). A great attention is paid to the analysis of the role of intensification of free radical oxidative reactions in the modification of lipid components of lipoproteins, blood proteins during the development and progression of cardiovascular diseases. Biochemical content, structural organization and main properties (barrier and ion-transport properties, receptors and antigens) of cellular membranes, the factors of neurohumoral regulation of metabolism, density and sensitivity of beta-adrenoreceptors, the activity of angiotensin converting enzyme, transmembrane ion gradients, concentration of intracellular calcium are studied. Biochemical criteria of patient selection for pathogenetically substantiated prescription of new drugs and the estimation of their efficacy have been developed in collaboration with other clinical departments of the Institute.
The modern methods of research are used at department, such as: differential ultracentrifugation, spectrophotometry, chromatography, nephelometry, radioligand binding, immunoenzymatic and other techniques.
During the last decade 280 scientific works were published, including 115 abroad, 5 guidelines, 15 inventions were patented. 7 candidate’s and 1 doctoral degrees in medicine have been given to the scientists of the department.