Scientific Director - T.I. Gavrilenko
The Department of Immunology
The department was founded in 1994.
The main direction of research is to study the significance of the parameters of cellular and humoral immune response and the level of immuno-inflammatory processes for the development of methods of pathogenetically substantiated treatment of patients with cardiovascular pathology. To this end complex immunological research is conducted to determine subpopulation content of lymphocytes and their proliferation capacity, functional condition of phagocytic cells (neutrophylic granulocytes, trigger factors for inflammation process within the vessel's wall, level of pro- and anti-inflamma¬tory cytokines (PNO-alpha, IL-1, IL-4, IL-6, IL-10), chemoattractants (IL-8, MCP-1), adhesion molecules (ICAM, VCAM), markers of endothelium dysfunction (endothelin) which is of great importance in the development and progressing of atherosclerosis.
Research is being conducted to determine available autoimmunization of the patient's organism as to the level of sensitization of immunocompeternt cells to tissue homogenates (from myocardium, aorta, cardiac valves, thyroid and pancreatic glands, liver, lungs, sinovial joint membrane), as well as examination of humoral autoimmune component based on the presence of antibodies to DNA, cardiolipine, antinuclear factor, cholesterol-containing complexes.
The role of infection factors in the development of cardiovascular diseases was established. The work is being carried out on modern tools: Becton Dickenson flow cytofluorimeter, immunoassay analyzer, Behring nephelometer-analyzer, etc.
During 10 years 162 scientific works were published, including 28 of them published abroad, 12 patents of invention obtained, 1 doctor of sciences and 5 PhDs prepared.
The main direction of research is to study the significance of the parameters of cellular and humoral immune response and the level of immuno-inflammatory processes for the development of methods of pathogenetically substantiated treatment of patients with cardiovascular pathology. To this end complex immunological research is conducted to determine subpopulation content of lymphocytes and their proliferation capacity, functional condition of phagocytic cells (neutrophylic granulocytes, trigger factors for inflammation process within the vessel's wall, level of pro- and anti-inflamma¬tory cytokines (PNO-alpha, IL-1, IL-4, IL-6, IL-10), chemoattractants (IL-8, MCP-1), adhesion molecules (ICAM, VCAM), markers of endothelium dysfunction (endothelin) which is of great importance in the development and progressing of atherosclerosis.
Research is being conducted to determine available autoimmunization of the patient's organism as to the level of sensitization of immunocompeternt cells to tissue homogenates (from myocardium, aorta, cardiac valves, thyroid and pancreatic glands, liver, lungs, sinovial joint membrane), as well as examination of humoral autoimmune component based on the presence of antibodies to DNA, cardiolipine, antinuclear factor, cholesterol-containing complexes.
The role of infection factors in the development of cardiovascular diseases was established. The work is being carried out on modern tools: Becton Dickenson flow cytofluorimeter, immunoassay analyzer, Behring nephelometer-analyzer, etc.
During 10 years 162 scientific works were published, including 28 of them published abroad, 12 patents of invention obtained, 1 doctor of sciences and 5 PhDs prepared.